Including nonspecific effects of vaccines and vitamin A in observational and randomized studies. Focus on implementation of the programmes and the consequences there of. Based on this platform, I evaluate the effects of campaigns and changes in vaccination policies. Bandim Health Project's HDSS is longitudionelt: all followed individuals are followed through repeated visits, enabling highly accurate measures of mortality in the area. The international organizations assess frequent changes in mortality patterns over time through serial cross-sectional studies, in which the individuals are not followed e. In collaboration with researchers from Johns Hopkins University and the London School of Hygiene and Tropical Medicine, we seek to examine how the methods used to measure early child mortality in such surveys can be improved. Observational studies suggest that the vaccination campaigns against polio and measles have significant beneficial effects on overall morbidity and mortality. Within the framework of Bandim Health Project's demographic surveillance system comprising village clusters and more than 18, children under 5 years, we will implement a cluster randomized trial. Both vaccines protect against polio, but their effect on general health is possibly very different: Previous studies have shown, that the living OPV protects against non-related diseases, where as the non-living polio vaccine IPV possibly increases the sensitiveness to a long list of infections, particularly for girls. Through a line of studies based on the observational data and data from randomized studies, Line will examine the real effects of OPV and IPV with a view to answer the questions about whether the change from OPV to IPV will increase child mortality and child sickness, when the child is deprived of the positive effects of OPV and instead exposed to the negative effects of IPV.
Kredse og lokalforeninger
Local study portals
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